In 2021, 4 years after the U.S. Department of Health and Human Services declared the opioid crisis a public health emergency, the Centers for Disease Control and Prevention reported that over 75% of overdose deaths in the United States involved an opioid, with nearly 88% involving a synthetic opioid. The use of naloxone to reverse opioid overdose decreases mortality and increases the potential for referral to substance use disorder treatment.
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